Approximately 20.5 million people in 2021 the whole world has succumbed cardiovascular diseaseaccounting for one-third of global mortality.

While certain risk factors such as gender, family history of disease, and ethnicity cannot be changed, preventable causes such as obesity, high cholesterol, high blood pressure, smoking, poor eating habits, and a sedentary lifestyle can reduce cardiovascular risk. contributes significantly to disease.

In a recent study by researchers, Cleveland Clinic Lerner InstituteA paper published in the journal Nature Medicine points to a potential link between elevated levels. Niacin, vitamin B3, cardiovascular disease.

Dr. Stanley Hazen, The study’s lead author explained that the study initially aimed to discover new pathways that contribute to heart disease beyond traditional risk factors. The study identified a compound called 4PY, a byproduct of niacin overdose, which is associated with future cardiovascular events, particularly heart attacks and strokes.

Niacin, also known as vitamin B3, helps turn food into energy and maintains the health of your skin and nervous system. Niacin can be obtained through food or supplements, but in excess it is excreted in the urine.

4PY may contribute to atherosclerosis

Analysis of plasma from individuals with stable cardiac health revealed a strong correlation between high levels of 4PY and the development of adverse cardiac events. However, Dr. Hazen cautioned against eliminating niacin completely and stressed the importance of consulting your doctor before taking over-the-counter supplements.

The study also found that excess 4PY causes blood vessel inflammation and contributes to atherosclerosis, a condition characterized by the buildup of plaque within arteries.

Dr. Chen Han Chen, Cardiologists said niacin was once prescribed to lower cholesterol, but its cardiovascular benefits have been called into question in recent studies.

Dr. Charles BrennerThe cardiovascular disease expert noted that the study was observational and no cause-and-effect relationship had been established. He emphasized the need for further research to understand the relationship between niacin supplementation and cardiovascular health.