Progressive hidradenitis suppurativa is increasingly associated with cSCC

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Progressive hidradenitis suppurativa (HS) is increasingly correlated with cutaneous squamous cell carcinoma (cSCC), according to new research findings. HS is a chronic inflammatory skin disease with the development of painful abscesses, painful nodules, and pus-draining sinuses localized on the skin in the axilla, groin, buttocks, and perianal area . Study results were discussed during a presentation at the 2024 American Academy of Dermatology (AAD) meeting, held from March 8, 2024 to March 12, 2024 in San Diego, California.

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Previously, HS was found to be associated with cSCC, but studies were limited by small enrolled sample sizes. This new study conducted a cross-sectional analysis of approximately 107 million hospitalized patients across the National Inpatient Sample (NIS) database. Patients with cSCC with or without HS between 2016 and 2018 were included, and the authors compared the number of cSCC hospitalizations with and without HS.

Results showed that the number of hospitalizations with HS had a 6-fold greater unadjusted odds ratio for cSCC than the number of hospitalizations without HS (OR = 6.21, 95% CI 4.18-9.21). After adjusting for age and sex, the odds ratio increased 13-fold (aOR = 13.37, 95% CI 8.99-19.88).

Furthermore, the HS patients who developed cSCC were older (53 years vs. 42 years; p < .0001) and more likely to be male (60.7% vs. 39.5%; p < 0.05) and blacks (48% vs. 47%). The study also showed that compared with other cSCC admissions, those with concomitant HS were less likely to be white and less likely to have cSCC in sun-exposed areas. Additionally, patients with concomitant HS were more likely to have not only the anal skin but also other regions of the trunk affected by her cSCC. Compared with other his cSCC hospitalizations, HS-related cSCC cases had higher hospitalization costs and patient length of stay.

The researchers noted that this study did not account for smoking or obesity due to the specificity of NIS-derived ICD codes (e.g., “trunk”) or the lack of these elements in inpatient coding. It points out that there are some limitations, such as the lack of Progressive HS is increasingly correlated with cSCC, as it affects anatomically distinct regions in a young and demographically diverse population. The authors conclude that early detection of HS patients by monitoring patients, especially black male patients, at age 40 and examination of photographic protected areas such as the torso and anal area is necessary to reduce morbidity and morbidity. points out. Mortality rate for this population.

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