Controlling for risk factors such as dyslipidemia and diabetes reduces the association between cardiovascular disease and HIV, a new study shows.

Controlling dyslipidemia and diabetes, but not hypertension, reduces the association between HIV infection and cardiovascular disease (CVD), according to a study published in the journal Clinical Infectionosis. Michael J. Silverberg, PhD, MPH, of Kaiser Permanente Northern California, and colleagues conducted a retrospective cohort of 8,285 people with HIV (PWH) and 170,517 people without HIV (PWoH) in an integrated health system. conducted research. The research team used a novel disease management index (DMI) that takes into account dose/duration above treatment goals (0%-100%) to assess risk factors including hypertension, dyslipidemia, diabetes, and other modifiable factors. Control factors were measured. [perfect control]). PWH and PWoH had similar DMI (80%-100%) except for triglycerides (worse in PWH) and hemoglobin A1c (better in PWH). When compared with PWh, PWH had an increased risk of CVD in the adjusted model (HR, 1.18). The association was attenuated in subgroups where dyslipidemia and diabetes were controlled. However, in PWH with controlled hypertension or high total cholesterol, this value remained elevated. The subgroup of frequent unhealthy alcohol users had the strongest association with HIV status and CVD (HR, 2.13).