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Lucknow: Researchers at King George Medical University (KGMU) blood marker It is called TNF-α (tumor necrosis factor alpha) and is useful in the early detection and treatment of various diseases. health conditionincluding chronic periodontal disease (periodontitis), obstructive sleep apnea syndrome (OSA) and heart disease.
Their study, titled “Assessing the association of obstructive sleep apnea with chronic periodontitis and coronary artery disease by assessing serum tumor necrosis factor,” was published in the peer-reviewed “Egypt Recently published in the academic journal.
Researchers in the Department of Periodontology, led by M.D. PhD student Shilpi Gupta, Ph.D., highlighted the importance of TNF-α as a key blood marker for early detection and treatment of these health conditions. .
Dr. Gupta emphasized, “Using TNF-α has the potential to enhance the treatment and management of these diseases, as until now there have been no reliable markers for these diseases.” For example, periodontal pocket depth was analyzed for periodontitis, and angiography was performed for heart disease. ”
He said they tested 300 people with periodontal disease, sleep disorders (OSA) and heart disease and compared them with 300 healthy people.
Blood samples were collected from each participant and analyzed for TNF-α levels using a dedicated PCR kit.
They found that TNF-α levels were significantly higher in the affected group, with a mean value of 54, compared to 38 in the healthy group. This suggests that individuals suffering from all three conditions have elevated TNF-α levels.
“Our findings also suggest a potential link between chronic periodontitis and CHD, as demonstrated by differences in TNF-α levels,” said Dr. Gupta.
Professor Umesh Pratap Verma, who supervised the study, highlighted the impact of the study: This study highlights the potential of TNF-α as a biomarker not only for periodontal disease but also for the early detection of sleep apnea and prediction of the severity of heart disease. ”
Their study, titled “Assessing the association of obstructive sleep apnea with chronic periodontitis and coronary artery disease by assessing serum tumor necrosis factor,” was published in the peer-reviewed “Egypt Recently published in the academic journal.
Researchers in the Department of Periodontology, led by M.D. PhD student Shilpi Gupta, Ph.D., highlighted the importance of TNF-α as a key blood marker for early detection and treatment of these health conditions. .
Dr. Gupta emphasized, “Using TNF-α has the potential to enhance the treatment and management of these diseases, as until now there have been no reliable markers for these diseases.” For example, periodontal pocket depth was analyzed for periodontitis, and angiography was performed for heart disease. ”
He said they tested 300 people with periodontal disease, sleep disorders (OSA) and heart disease and compared them with 300 healthy people.
Blood samples were collected from each participant and analyzed for TNF-α levels using a dedicated PCR kit.
They found that TNF-α levels were significantly higher in the affected group, with a mean value of 54, compared to 38 in the healthy group. This suggests that individuals suffering from all three conditions have elevated TNF-α levels.
“Our findings also suggest a potential link between chronic periodontitis and CHD, as demonstrated by differences in TNF-α levels,” said Dr. Gupta.
Professor Umesh Pratap Verma, who supervised the study, highlighted the impact of the study: This study highlights the potential of TNF-α as a biomarker not only for periodontal disease but also for the early detection of sleep apnea and prediction of the severity of heart disease. ”
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