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heart disease concept

A recent study conducted by the German Diabetes Research Center and associated institutions has identified a novel protein biomarker that predicts the risk of developing coronary heart disease in patients with and without type 2 diabetes. This breakthrough provides new insights into the mechanisms of this disease and potential means of prevention and treatment.

Coronary heart disease (CHD) is a significant health challenge worldwide, especially for people with type 2 diabetes. Scientists from the German Diabetes Research Center (DZD), Helmholtz München and Ludwig-Maximilians-University Munich (LMU) have discovered a new protein biomarker associated with the development of CHD in both diabetic and non-diabetic patients.

The results were announced below. Cardiovascular Diabetology.

Importance of CHD and increased risk for diabetic patients

Coronary heart disease (CHD) is one of the most common causes of death worldwide, particularly in Europe, accounting for almost half of all deaths. Among middle-aged adults, those with type 2 diabetes (T2D) are 2 to 4 times more likely to develop CHD than those without T2D.

The research team investigated the predictive performance of protein biomarkers for the development of CHD in patients with and without T2D.

Research methods and findings

In the study, researchers used data from the Augsburg Region Collaborative Health Research (KORA). The validation cohort included 888 participants in the KORA-Age1 study, who developed 70 cases of CHD during 6.9 years of follow-up (19 vs. 51 in the T2D and no T2D groups, respectively) . They tested 233 blood samples from test subjects. plasma proteins related to cardiovascular disease and inflammation.

The researchers thus identified two proteins associated with the development of CHD in patients with diabetes and 29 proteins in patients without baseline T2D. Six of these proteins are novel candidates for CHD development.

The results of this study significantly contribute to a deeper understanding of the pathophysiology of CHD in T2D patients and provide potential new approaches to the prevention and treatment of this serious complication. They highlight the importance of further research in this field and the role of the German Diabetes Research Center in solving pressing problems related to diabetes and its complications.

Reference: “Association between plasma proteomics and the development of coronary heart disease in patients with and without type 2 diabetes: Results from the population-based KORA study” Hong Luo, Marie-Theres Huemer, Agnese Petrera, Stefanie M. Hauck, Wolfgang Rathmann, Christian Herder, Wolfgang König, Annika Heuer, Annette Peters, Barbara Soland, February 3, 2024. Cardiovascular Diabetology.
DOI: 10.1186/s12933-024-02143-z



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