Experts develop model that can be rapidly implemented for better diagnosis and treatment in The Lancet

(New Brunswick, New Jersey) – Approximately 25,000 Americans die each year from heart valve disease, but researchers at Rutgers Health and other institutions have concluded that new technology could soon help doctors reduce that number. There is.

“We are witnessing a paradigm shift in how valvular heart disease is diagnosed and treated,” said Henry Henry Professor of Cardiology at Rutgers University and director of the Division of Cardiovascular Disease and Hypertension at Rutgers Robert Wood Johnson Medical School. said Partho Sengupta.

Sengupta, also chief of cardiology at Robert Wood Johnson University Hospital, an RWJ Barnabas Medical Facility, is the paper’s lead author. lancet Learn which technologies currently exist and which are coming soon. “It will be important to learn and embrace the impending winds of change.”

Valvular heart disease, a disease in which one of the heart’s four valves becomes damaged or diseased, affects 2.5 percent of all Americans and 13 percent of Americans over age 80. Most cases are not diagnosed until symptoms have progressed to the point where symptoms such as shortening of the heart appear. Breathing, chest pain, fatigue. If detected early, treatment can help prevent progression and improve quality of life.

Doctors have traditionally detected heart valve disease simply by listening with a stethoscope, but new technology is improving diagnosis. Research has shown that AI can detect infrasonic heart murmurs at frequencies too low to be heard by the human ear. moreover,

Electrocardiograms and wearable devices that record the heart’s electrical activity use artificial intelligence (AI) to capture the data needed to identify possible cases of valvular heart disease from variations in heart rate, blood pressure, blood oxygenation, and other factors. ) can be provided. Such a device could not only detect the disease in its early stages, but also monitor disease progression after diagnosis, the researchers wrote.

Primary care physicians may also play a greater role in early diagnosis. Few medical institutions currently have the equipment or expertise to diagnose valvular heart disease, but recent research demonstrates that healthcare professionals can combine portable ultrasound devices with AI to diagnose heart disease. It has been. With such technology, screening for heart valve disease could become part of routine testing for high-risk patients.

AI algorithms have the potential to further improve care by developing a digital twin of each patient using data from ultrasound and other imaging devices. This digital twin can simulate how treatments and surgeries will work for each individual to improve accuracy in choosing the actual treatment for each patient.

“The concepts I wrote about in this paper are also at the core of what we do at the Innovation Center at Robert Wood Johnson University Hospital, a RWJBarnabas Health facility. “Since opening our doors in partnership, we have brought together clinicians, researchers, and private companies to invent and develop innovative technologies,” said Sengupta, who leads the center, adding that these innovations are simply He added that he believes in more than just helping medical care. This will not only improve early detection, but also deepen the understanding needed to develop new treatments.

There are currently no drugs approved to treat valvular heart disease, but there are ongoing trials aimed at changing this situation. Because cholesterol can cause or worsen some types of heart valve disease, drug companies are testing statins and PSK9 inhibitors (which lower cholesterol even more than statins) for aortic stenosis. ing.

Additionally, a retrospective analysis of diabetes drug trials found that a class of drugs called DPP-4 inhibitors seemed to slow the progression of aortic stenosis, thus helping to maintain nitric oxide levels around Prospective trials of these drugs that appear to fight the disease are underway. Valve tissue. Rutgers University and his RWJBarnabas Health are now offering these experimental treatments to patients in a clinical trial testing strategies to halt the progression of valvular heart disease long before surgery is needed.

This paper highlights the timely surgery and advances in transcatheter valve replacement, which does not require a large opening in the chest, making it a less invasive alternative to traditional surgery for certain patients. There is. However, the difference increases over time because the prosthetic valve tissue performs worse than the body’s own valve tissue and cannot regenerate itself as the body ages. It is broken down in a way that never happens in a functional organization that constantly rebuilds itself.

However, a new generation of more flexible prostheses that promise better performance is in clinical trials. Researchers are developing an absorbable valve prosthesis that the body will eventually replace with a functioning organic valve, just as proteins constantly replace existing tissue with new tissue as they wear out.These are especially true

This is valuable for young patients who may require several sets of replacement valves throughout their lifetime.

“The innovation, discovery, and future of clinical care that we envisioned at Rutgers University is now possible. of lancet, And it’s encouraging that this roadmap can also be adopted globally to fight valvular heart disease,” said Sengupta, a Rutgers University physician and member of the RWJBarnabas Health Medical Group.

About Robert Wood Johnson University Hospital

Robert Wood Johnson University Hospital (RWJUH) New Brunswick, an RWJ Barnabas Medical Facility, is a 640-bed academic medical center that is the largest academic medical center in New Jersey through a deep partnership with Rutgers Robert Wood Johnson Medical School. . RWJUH is a flagship cancer hospital at Rutgers Cancer Institute in New Jersey and a Bristol-Myers Squibb Children’s Hospital within Robert Wood Johnson University Hospital, and is a 2023-24 Best in America by U.S. News & World Report. Ranked among children’s hospitals. The Center of Excellence includes cardiovascular treatments ranging from minimally invasive heart surgery to transplantation, cancer treatment, stroke treatment, neuroscience, orthopedics, bariatric surgery and women’s health. A Level 1 trauma center and the province’s first designated pediatric trauma center, his RWJUH’s New Brunswick campus serves as a national resource in an innovative approach to emergency preparedness. .

RWJUH receives nationally significant recognition for clinical quality and patient safety, including receiving the prestigious Magnet® Recognition for Nursing Excellence and being named to Newsweek’s 2023 list of Best Ambulatory Surgery Centers doing. RWJUH Advanced Comprehensive Stroke Center has been recognized by the Joint Commission and the American Heart Association as meeting the Joint Commission’s standards for Advanced Accreditation of Disease-Specific Care Comprehensive Stroke Centers. RWJUH also holds the Joint Commission’s Gold Seal of Approval® for Disease-Specific Care Certification for Spine Surgery. Joint Commission Gold Seal Certification for Obesity Treatment Services. Joint Commission Gold Seal Certification for Hip and Knee Replacement Services. The Joint Commission also awarded RWJUH Gold Seal Certification and Advanced Certification in Ventricular Assist Device (VAD) Implantation.

About Rutgers Robert Wood Johnson Medical School

As one of the nation’s leading comprehensive medical schools, Rutgers Robert Wood Johnson Medical School is dedicated to the pursuit of excellence in education, research, health care delivery, and promotion of community health. Robert Wood Johnson Medical School, part of Rutgers, The State University of New Jersey, includes 20 basic science and clinical departments, including the Heart and Vascular Institute, New Jersey Child Health Research Institute, and Women’s Health. It has several centers and research institutes.

Institute. The School of Medicine is recognized as one of the top 100 medical schools in the nation by U.S. News & World Report and ranked No. 1 in the state for research and primary care.

Robert Wood Johnson Medical School and Robert Wood Johnson University Hospital, RWJ Barnabas Medical Facility, are the School of Medicine’s primary affiliates and make up one of the nation’s premier academic medical centers. Clinical services are provided by her more than 500 faculty members in more than 200 specialties and subspecialties as part of Rutgers Health, the clinical division of Rutgers University. For more information about Rutgers Robert Wood Johnson Medical School, visit rwjms.rutgers.edu.

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