Systemic inflammation is associated with increased risk of chronic kidney disease, according to a study published online on February 20. Frontiers of immunology.

Xiaoxin Liu and colleagues at Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China, investigated the relationship between systemic immune inflammatory index (SII) and chronic kidney disease. This analysis included 10,787 adults who participated in the 2018 National Health and Nutrition Examination Survey from 2007 to 2018.

The researchers found that, after adjusting for confounders, higher SII was associated with an increased risk of developing chronic kidney disease (odds ratio, 1.36). His restricted cubic spline curve showed a positive nonlinear correlation between his SII per 1,000 people and the incidence of chronic kidney disease. Stronger correlations were observed for men (odds ratio, 2.628) and women (odds ratio, 1.733).

“Our findings suggest that higher SII values ​​are associated with the incidence of chronic kidney disease and that this effect is more pronounced in the male population,” the authors wrote. “A number of pathophysiological changes contribute to the development of chronic kidney disease, and immune dysfunction and increased inflammation may play important roles in this process.”

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