Announcement of new article publication Cardiovascular innovations and applications journal. Assessment of endothelial function is critical to understanding the progression of cardiovascular disease. Reliable and convenient non-invasive methods are needed to assess endothelial function. Peripheral arterial volume (PAV) measured with a fingertip is a new approach with limited reproducibility data. Therefore, this study aimed to evaluate the reproducibility of PAV measurements in a clinical setting.

A total of 152 consecutive patients (mean age 55.8 ± 12.3 years, 83 men) with chest pain were included in the study. A PAV test was also performed on the same day. The amplitude ratio before and after applying pressure was recorded along with the reference ratio, and the PAV was calculated. Medical baseline data for these patients were collected from hospital records.

On test day, the repeated measures PAV results were 1.15 ± 0.33 and 1.15 ± 0.31 (P = 0.99), indicating no significant difference between measurements for all participants. The mean difference was 0.00 ± 0.32, indicating no systematic error, and the intraclass correlation coefficient was 0.66. Furthermore, age, gender, and BMI did not affect the reproducibility of PAV.

PAV measurements were feasible and showed excellent reproducibility among all enrolled patients. As a new fingertip measurement, PAV holds promise as a convenient and accurate method to assess endothelial function in adults.