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Previous research has linked niacin, a B vitamin found in fortified flours and cereals, to lower levels of low-density lipoprotein (LDL) cholesterol. However, taking niacin supplements has not been associated with a reduced risk of cardiovascular disease in people who also take statins. Researchers call this contradiction a “contradiction.” The niacin paradox.

Now, recent research results are natural medicine A study of more than 4,300 participants with stable heart disease suggests that too much niacin can cause inflammation of blood vessels and increase the risk of cardiovascular disease.

Researchers found that people with too much of a particular breakdown product of niacin in their blood were less likely to have serious heart problems such as stroke, myocardial infarction, and death over a three-year period than those with less niacin. We found that there was a tendency to be at high risk. .

Excess levels of these breakdown products in people may come from eating too many niacin-fortified foods or taking too much B vitamins.3 supplements, or having a genetic variation that is also associated with inflammation. That said, the findings “raise the question of whether continued mandates for fortifying flour and grains with niacin are justified,” the researchers wrote.

Published online: March 6, 2024. doi:10.1001/jama.2024.1566

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