heartdiseasefacts.com
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March 2, 2024
2 minute read
Important points:
- Schizophrenia is associated with an increased risk of heart disease in both men and women, with women at higher risk.
- Researchers said promoting physical activity is important for women at CV risk.
Epidemiological data show that women with schizophrenia are 63% more likely to develop CVD during a 3.5-year follow-up compared to women without schizophrenia, and a higher risk is observed in obese women.
“Prevention of cardiovascular disease in women is of paramount importance in current clinical practice.” Hidehiro Kaneko, Doctor of Medicine; An associate professor at the University of Tokyo told Helio. “Based on our findings, it should be recognized that the presence of schizophrenia in women is associated with a greater risk of developing cardiovascular disease than in men.”
Schizophrenia is associated with an increased risk of heart disease in both men and women, with women at higher risk. Image: Adobe Stock
In a retrospective study of insurance claims data, Kaneko et al. analyzed data on 4,124,508 adults without baseline CVD or renal replacement therapy. Median patient age was 44 years, and 57% were male.
The primary outcome was a composite of cardiovascular events including myocardial infarction, angina pectoris, stroke, heart failure, atrial fibrillation, and pulmonary thromboembolism.
Within the cohort, 0.64% of men and 0.92% of women had schizophrenia. Both men and women had higher prevalence of obesity, hypertension, diabetes, dyslipidemia, and physical inactivity in individuals with and without schizophrenia.
During a mean follow-up period of 1,288 days, 119,827 CVD events occurred in men, with an incidence rate of 141.1 per 10,000 person-years, and 62,331 CVD events occurred in women, with an incidence rate of 112 events per 10,000 person-years. was.
The HR for the composite CV endpoint in patients with schizophrenia was 1.63 (95% CI, 1.52 to 1.74) for women and 1.42 (95% CI, 1.33 to 1.52) for men. P interaction = .0049).
In analyzes stratified by CVD type, the HR for MI in patients with schizophrenia was 1.31 (95% CI, 0.84-2.04) for women and 1.04 (95% CI, 0.78-1.4) for men. The HR for angina was 1.53 (95% CI, 1.38 to 1.7) in women and 1.33 (95% CI, 1.2 to 1.48) in men. The HR for stroke was 1.42 (95% CI, 1.21-1.66) in women and 1.49 (95% CI, 1.29-1.73) in men. HR for heart failure was 1.8 (95% CI, 1.64-1.97) in women and 1.42 (95% CI, 1.29-1.56) in men. The HR for AF was 1.44 (95% CI, 1.09-1.9) in women and 1.02 (95% CI, 0.82-1.27) in men. The HR for pulmonary embolism was 2.78 (95% CI, 1.89-4.08) in women and 1.93 (95% CI, 1.23-3.04) in men.
Researchers found that among obese people, there was a stronger association between schizophrenia and CVD in women than in men.
The researchers noted that the findings suggest that health care providers should incorporate routine screening and treatment for schizophrenia into standard clinical practice for everyone. did.
Hidehiro Kaneko
“We found a strong association between schizophrenia and subsequent risk of developing cardiovascular disease, and this association was more pronounced in women,” the researchers wrote. “Our results suggest the need for further support for people with schizophrenia, especially women. Psychiatrists, cardiologists and general practitioners should share:
Take advantage of the results of this study and apply it to cardiovascular disease prevention, especially in women. ”
For more information:
Hidehiro Kaneko, Doctor of Medicine; Please contact kanekohidehiro@gmail.com. X (Twitter): @kanehidehiro.
Information source/disclosure information
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Disclosure:
Mr. Kaneko reported receiving research and scholarship funding from Biotronic Japan, Boston Scientific Japan, Fukuda Denshi, Medtronic Japan, and Simplex Quantum. Please refer to this study for relevant financial disclosures of all other authors.
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