NEW YORK, NY — High CPAP pressures may explain why machines fail to lower heart disease risk, which is about two to three times higher than average, in a study of people with obstructive sleep apnea It was suggested that there is.

“While CPAP machines are highly effective in treating obstructive sleep apnea and are great for improving sleep and reducing daytime fatigue, they have not shown the reduction in heart disease that we had hoped for. We still don’t know why,” says Sanja Jelic. Doctor. A critical care medicine specialist and sleep researcher at Columbia University Vagelos College of Physicians and Surgeons.

CPAP and inflammation

Obstructive sleep apnea, which affects approximately 25% of adults in Western societies, occurs when the muscles of the upper airway relax and the airway collapses during sleep. The subsequent infiltration of oxygen often wakes people up, and in extreme cases it wakes up every two minutes, leading to daytime fatigue.

“Oxygen levels can go up and down overnight,” says Jerick. Repeated drops in oxygen levels lead to increased inflammation, which is thought to cause an increased risk of heart disease associated with obstructive sleep apnea.

Because CPAP machines restore normal breathing during sleep (by using positive air pressure to keep the upper airways open), researchers believed that CPAP also reduced patients’ risk of heart disease. .

But a few years ago, research conducted by Gerrick and Dr. Daniel Gottlieb, a collaborator at Brigham and Women’s Hospital, began to suggest problems with this hypothesis. A study designed to understand the effects of CPAP on the body found that CPAP use did not reduce levels of the pro-inflammatory factor angiopoietin-2. Previous studies have linked high levels of Ang2 to increased rates of stroke, coronary artery disease, vascular disease, and mortality.

“That was a surprise. We expected, of course, that once we got rid of the intermittent hypoxia with CPAP, the Ang2 release would stop, but it actually got worse,” says Jelic.

Around the same time, results from three randomized trials of CPAP came in, none of which found any cardiovascular benefits for the machine.

Jerick said the pattern of Ang2 and other biomarkers in CPAP users is similar to that of patients on hyperbaric ventilators, and that CPAP pressure may be the reason the expected reduction in heart disease did not materialize. We hypothesized that this could be explained by the height of .

new analysis

To dig deeper, Geric and Gottlieb took a closer look at participants in the first trial, RICCADSA, conducted in Sweden with 189 patients with obstructive sleep apnea. The researchers analyzed the stored blood samples for Ang2 and other inflammatory markers and compared those numbers to CPAP adherence, median CPAP pressure, and the patients’ heart health one year later.

Their analysis showed that Ang2 levels remained elevated in CPAP users, confirming Gerrick’s previous findings in a small study, and also found that high Ang2 levels were It was found that the risk of cardiovascular disease increases after a month.

The researchers then discovered that patients with the highest Ang2 levels were those using higher CPAP pressures. Standard CPAP prescriptions use pressures ranging from 4 to 20 cm H2O, with the median pressure varying within that range. In this study, participants with a median CPAP pressure of 4 to 7 had fewer cardiovascular events compared to participants who used a pressure of 8 or higher. No correlation was found between Ang2 levels and the number of hours she used CPAP at night.

“This suggests that there is something in the lungs that responds to CPAP pressures that perpetuates rather than reduces the inflammation associated with obstructive sleep apnea,” says Gerrick.

Effect of pressure

Because CPAP is known to expand the lungs, although not as dramatically as a ventilator, Jerick believes that the expanded endothelial cells in the lungs release extra Ang2. Although it is not possible to directly measure Ang2 release from human lungs, stretching other tissues in clinical tests rapidly increases Ang2 release from endothelial cells.

Jerick is already changing the way he uses CPAP for his sleep apnea patients.

“I’ve been prescribing lower pressures,” she says. “We’re making careful adjustments to see which pressures eliminate most of the blocking events, and it’s working just fine.”

Most doctors now adjust CPAP pressure to eliminate all obstructive episodes during sleep. But even if some obstructive symptoms occur, Jerrick says, lowering the pressure may reduce Ang2 and provide the same sleep and fatigue improvements.

“That would need to be tested in a randomized trial,” she says.

For more information

“CPAP may promote an endothelial inflammatory environment in sleep apnea after coronary artery revascularization,” was published February 24 in the Lancet’s eBiomedicine.

All authors: Yuksel Peker (Koç University Faculty of Medicine, Turkey), Yeliz Celik (Koç University), Afrouz Behboudi (Skovde University, Sweden), Susan Redline (Brigham & Women’s Hospital, Boston), Jing Lyu (Columbia), Ying Wei (Columbia) ), Daniel J. Gottlieb (Harvard University, Brigham & Women’s Hospital, VA Boston Healthcare System), and Sanja Jelic (Columbia).

###

Columbia University Irving Medical Center

Columbia University Irving Medical Center (CUIMC) is a clinical, research, and educational campus located in New York City and one of the oldest academic medical centers in the United States. CUIMC is home to his four professional colleges and schools that are world leaders in their fields: Vagelos College of Physicians and Surgeons, Mailman School of Public Health, School of Dentistry, and School of Nursing. CUIMC is committed to providing comprehensive and equitable health and medical education, scientific research, and patient care, and working with the local Upper Manhattan community, one of New York City’s most diverse regions. For more information, visit cuimc.columbia.edu.