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February 25, 2024
2 minute read
Important points:
- Genetic major depressive disorder was associated with genetic factors in PAD.
- The association between genetic depression and PAD was completely attenuated after adjusting for lifetime smoking and BMI.
Increased propensity for peripheral arterial disease in patients with major depression may be mediated by increased lifetime smoking prevalence and body mass index, a study has found. journal of the american heart association.
Researchers reported that a genetic predisposition to major depressive disorder was not associated with a tendency to increase alcohol consumption.
“According to the World Health Organization, major depressive disorder is the leading cause of disability worldwide. [more than] 300 million people. Observational studies have associated depression and depressive symptoms with her PAD and PAD outcomes, suggesting the comorbid nature of the two conditions. ” Gabriel Schacht, B.S., and colleagues from the Department of Surgery at the Corporal Michael J. Cressenz VA Medical Center in Philadelphia, wrote: “Despite observational evidence linking major depressive disorder to PAD and its risk factors, evidence of causation of these associations is lacking.”
Shakt and colleagues conducted this study using Mendelian randomization to examine the causal relationship between the genetic predisposition to major depressive disorder and the genetic predisposition to PAD.
The study was conducted in three phases. In the first step, researchers tested the association between genetic factors of major depressive disorder and PAD. In the second step, we tested the mediators linking major depressive disorder and his PAD. And in the third step, the researchers adjusted for the mediators identified in the second step to establish an independent association between the genetic responsibility for major depressive disorder and the genetic responsibility for his PAD. tested.
Data on major depressive disorder were obtained from a large Psychiatric Genomics Consortium analysis of over 135,000 patients. The PAD data came from a genome-wide association study in the Department of Veterans Affairs’ Million Veterans Program, which included 31,307 patients with PAD.
In the first phase of the study, Shakt et al. reported that genetic predisposition to major depressive disorder was associated with increased propensity for PAD (OR = 1.17; 95% CI, 1.06-1.29; P = 2.64 × 10–3).
In the second step, genetic factors for major depressive disorder were associated with increased genetically determined lifetime smoking (beta = 0.11; 95% CI, 0.078-0.14; P = 1.2 × 10–12) and BMI (beta = 0.1; 95% CI, 0.02-0.19; P = 1.8 × 10–2), each of which was associated with a genetic predisposition to PAD (OR for smoking = 2.81; 95% CI, 2.28-3.47; P = 9.8 × 10-twenty two; OR if BMI = 1.61; 95% CI, 1.52-1.7; P = 1.3 × 10–57).
Genetic propensity for major depressive disorder was not associated with increased alcohol intake (beta = 0.078; 95% CI, 0.15 to 0; P = .043), thus this was not associated with increased PAD liability (OR = 0.77; 95% CI, 0.66-0.88; P = 1.8 × 10-Four).
In the third stage, after controlling for lifetime smoking, alcohol intake, and BMI, the association between genetic factors of major depressive disorder and genetic factors of PAD was completely attenuated.
“One in five people with PAD also has depression, which is associated with worse limb outcomes and increased all-cause mortality,” the researchers wrote. “Our results demonstrate that both addressing the underlying depression and mental health, as well as addressing the risk factors exacerbated by depression, offer an opportunity to reduce the risk of PAD and improve patient outcomes. It suggests that.”
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Disclosure: Schact does not report any relevant financial disclosures. Please refer to this study for relevant financial disclosures of all other authors.
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