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In this latest study, researchers used clinical, genetic, and mouse data to examine the effects of niacin on cardiovascular disease. They tested blood samples from more than 1,100 stable heart patients at the heart center.
The results of this study revealed that excess niacin in the blood leads to the production of a substance called 4PY, which researchers believe is linked to an increased risk of cardiovascular disease. This led researchers to launch two additional studies, including one that focused on 2,300 U.S. patients and 800 European heart patients, and a smaller study that focused on the effects in mice. It was decided that the department would be implemented.
The data showed that the presence of excess niacin and 4PY accurately predicted an increased risk of serious adverse cardiovascular events, including an increased risk of heart attack, stroke, and death. The higher the level of 4PY, the more likely you are to have a cardiac event.
When researchers injected 4PY into mouse subjects, the mice experienced increased levels of inflammation in their blood vessels, which previous studies have reported to be associated with an increased risk of heart disease.
Researchers said the results of the new study should help change some of the overuse of niacin. They recommended that the food industry stop using niacin in foods and that doctors should not recommend it to patients at risk for cardiovascular disease.
Because this vitamin has pro-inflammatory effects, the researchers also called for changes in dietary recommendations for patients who may be at higher risk of suffering a heart attack or stroke.
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