Important points:

• Amblyopia in childhood was associated with increased cardiometabolic risk in adulthood.
• A causal relationship between persistent amblyopia and future cardiometabolic risk could not be established in this study.

Amblyopia, or “lazy eye” in childhood, is associated with an increased likelihood of cardiometabolic risk factors and an increased risk of heart attack and death in adulthood, researchers reported.

Data did not show a causal relationship between cardiometabolic disease in adulthood and childhood amblyopia, according to study results published in . e-clinical medicine.

‘Amblyopia is an eye disease that affects four in 100 children. In the UK, all children should have their vision tested before the age of five to ensure prompt diagnosis and appropriate eye treatment. I am supposed to take it.” Jugnu Rahi, FMedSci, Professor of Ophthalmic Epidemiology at University College London (UCL) Great Ormond Street Institute of Child Health and UCL Eye Institute and Great Ormond Street Hospital said in a press release. “Markers associated with increased risk of serious illness in adulthood are rarely present in childhood, and thanks to population screening, there are no known markers that are measured in all children. ” is also rare.

“The large number of affected children and their families may wish to consider our findings as further motivation to achieve a healthy lifestyle from an early age,” Rahi said. said in a release.

In this observational study, ra, Siegfried curl Dr. Wagner, Honorary Clinical Senior Research Fellows from the UCL Institute of Eye Research and Honorary Clinical Research Fellows from Moorfields Eye Hospital conducted a cross-sectional analysis of 21,702 UK Biobank participants using complete ophthalmological and demographic data.

Within this cohort, 14.8% had a confirmed diagnosis of amblyopia, which was defined as self-reported amblyopia or strabismus, significant anisometropia, significant astigmatism, significant refractive error itself, or less severe visual impairment. This was defined as treatment supported by the patient’s condition, and no other underlying or eye disease was observed. Direct vision.

Participants with amblyopia were dichotomized as either “resolved” amblyopia, with current normal or near-normal vision, or “persistent” amblyopia, where visual impairment remained despite childhood treatment.

Overall, 82.2% of amblyopic participants had persistent amblyopia.

Wagner et al. found that people with persistent amblyopia were more likely to have obesity (adjusted OR = 1.16; 95% CI, 1.05-1.28), hypertension (aOR = 1.25; 95% CI, 1.13-1.38) and diabetes (aOR = 1.29). I have observed that this is likely. ; 95% CI, 1.04-1.59) compared to people without amblyopia.

Additionally, this study found that amblyopia was also associated with increased risk of MI (aHR = 1.38; 95% CI, 1.11-1.72) and death (aHR = 1.36; 95% CI, 1.15-1.6).

View the full study for more details on the retinal characteristics of both the amblyopic and unaffected non-amblyopic eyes of the study participants.

“We emphasize that our study does not show a causal relationship between amblyopia and poor health in adulthood,” Wagner said in the release. “Our study means that the ‘average’ adult who had amblyopia as a child is more likely to develop these disorders than the ‘average’ adult who does not have amblyopia.” To do. The results of this study do not mean that all children with amblyopia will develop cardiometabolic disorders as adults. ”

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